The NIH has a pretty cool monthly podcast called “Pinn Point on Women’s Health,” which is hosted by Dr. Vivian Pinn, director of the NIH’s Office of Research on Women’s Health. For September, the topic was Autoimmune Disease in women (NIH summary and directions for downloading the podcast can be found here.)

The topic is fascinating! Autoimmune diseases are those where the body , for whatever reason, starts fighting its own cells with an immune response in the same way it would if the cells were a foreign invader (bacteria, virus etc). Women are more likely to get a whole host of autoimmune diseases than men are, including multiple sclerosis, rheumatoid arthritis, and lupus. Apparently, out of all the people suffering from auto-immune diseases in the US, 80% are female. That’s a phenomenal bias for a condition that, on the surface at least, has no clear tie to gender. According to the research (great review here), our increased risk of getting these diseases is simply our great immune systems working against us. Apparently, our immune systems are so great that we’re less prone to infection and have a much greater antibody response to those little invaders that do get in. Unfortunately, our systems are so strong that they also tend to go into overdrive, leading to this attack of our own bodies. The culprits (or overachieving heroes, depending on how you look at it), are likely exactly what you’d expect: hormones or chromosomal influences. The hormone research actually shows that during pregnancy, women's immune systems switch to a far less aggressive regimen, likely to avoid attacking the fetus as an invader. This decreased immunity is the reason for the increased risk of pregnant women getting the flu that Alison mentioned, but it’s also the reason that many pregnant women notice a decrease in their symptoms of autoimmune disorders. I actually have/had a condition called tranverse myelitis, which is thought to be an autoimmune disorder; I also very rarely catch the normal seasonal bugs that float around the office, and I don’t think I’ve ever had the flu (knock on wood!). It’s kind of amazing to think that both the bad and the good stem from the same source: an incredibly strong immune system! Anyone else notice that same thing in his/her self, or anyone they know with autoimmune disorders?

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Comments

I think the immune system going into overdrive happens for a reason. Most likely that reason is the body has ingested something foreign. Very easy to do with all the chemicals we come into contact with on a daily bases. Popular Science did an article and tested a guy for 100's of different chemicals. He was absolutely shocked at what the test reveled.

this is new Holy Grail of genetic industry. I read a lot of articles and everything is pointing in this direction.

Gene mapping is progressing at the lightnig speed... this is new Holy Grail of genetic industry. I read a lot of articles and everything is pointing in this direction.

I also had an autoimmune form of arthritis for years and seldom get colds or the flu. I think there is something to what you say about an overly strong immune system having both an up and a down side. Barbara Allan, author of the book Conquering Arthritis

I guess this is a question more than a comment. During your observations and gathering of information, do you feel like there is an awareness of the differences between male and female soldiers? To the point that these differences warrant modification and implementation of a separate male and female wardrobe in the armed services?

Love how you mentioned rheumatoid arthritis in your list of diseases about autoimmune diseases. People need to know about that. Thanks for the post, Candace!