Posted by on September 13, 2011 - 6:55am

No bones about it:  eating prunes helps prevent fractures and osteoporosis.   When it comes to improving bone health in postmenopausal women — and people of all ages, actually — a Florida State University researcher has found a simple, proactive solution to help prevent fractures and osteoporosis: eating dried plums.

“Over my career, I have tested numerous fruits, including figs, dates, strawberries and raisins, and none of them come anywhere close to having the effect on bone density that dried plums, or prunes, have,” said Bahram H. Arjmandi, of  Florida’s chairman of the Department of Nutrition, Food and Exercise Sciences in the College of Human Sciences. “All fruits and vegetables have a positive effect on nutrition, but in terms of bone health, this particular food is exceptional.”

Arjmandi and a group of researchers from Florida State and Oklahoma State University tested two groups of postmenopausal women. Over a 12-month period, the first group, consisting of 55 women, was instructed to consume 100 grams of dried plums (about 10 prunes) each day, while the second — a comparative control group of 45 women — was told to consume 100 grams of dried apples. All of the study’s participants also received daily doses of calcium (500 milligrams) and vitamin D (400 international units).

The group that consumed dried plums had significantly higher bone mineral density in the ulna (one of two long bones in the forearm) and spine, in comparison with the group that ate dried apples. This, according to Arjmandi, was due in part to the ability of dried plums to suppress the rate of bone resorption, or the breakdown of bone, which tends to exceed the rate of new bone growth as people age.

The group’s research, “Comparative Effects of Dried Plum and Dried Apple on Bone in Post Menopausal Women,” was published in the British Journal of Nutrition.  In the United States, about 8 million women have osteoporosis because of the sudden cessation of ovarian hormone production at the onset of menopause. What’s more, about 2 million men also have osteoporosis.

“In the first five to seven postmenopausal years, women are at risk of losing bone at a rate of 3 to 5 percent per year,” Arjmandi said. “However, osteoporosis is not exclusive to women and, indeed, around the age of 65, men start losing bone with the same rapidity as women.”

Arjmandi encourages people who are interested in maintaining or improving their bone health to take note of the extraordinarily positive effect that dried plums have on bone density.

“Don’t wait until you get a fracture or you are diagnosed with osteoporosis and have to have prescribed medicine,” Arjmandi said. “Do something meaningful and practical beforehand. People could start eating two to three dried plums per day and increase gradually to perhaps six to 10 per day. Prunes can be eaten in all forms and can be included in a variety of recipes.”

Source: Florida State University

Posted by on June 24, 2011 - 10:07am
Testosterone Molecule

Testosterone might protect the memory of healthy aging women, according to a small open-label pilot study reported at the Endocrine Society 93rd Annual Meeting held in June 2011.  Nine postmenopausal women who used a transdermal testosterone spray for about 6 months saw improvements over baseline in verbal learning and memory. A group of matched untreated women saw no change from baseline in their test results. The study was small and further exploration is needed but the idea has merit.

"The results of our study offer a potential therapy, where none currently exists, to slow cognitive decline in women," said lead investigator Sonia Louise Davison, MD, PhD, from the Women's Health Research Program at Monash University in Melbourne, Australia. "Testosterone should be further studied in randomized placebo-controlled trials to determine whether it improves cognitive performance in postmenopausal women," she added.

At a press briefing, Dr. Davison said predictions of the number of people who will develop dementia in the coming years are "pretty worrying." Dementia is set to become an "enormous" and costly public health problem. Women develop dementia at double the rate of men; lower testosterone levels in women might play a role in this sex difference.

Dr. Davison's team explored the effects of testosterone on cognitive performance in 9 nondepressed cognitively normal women. The women were between 47 and 60 years of age (mean age, 55 years) and were receiving stable-dose hormone replacement therapy that was not administered orally. They applied the testosterone spray to the abdomen once daily for 26 weeks. A control group of 30 women provided normative data for comparison.At baseline and 26 weeks, all of study subjects took a computerized cognitive test battery, called CogState, which is capable of detecting small changes in cognitive performance, Dr. Davison explained.

There were no differences between the 2 groups in any parameter at baseline.After 26 weeks, "significant improvements" from baseline were observed in learning (verbal and visual) and memory in the testosterone group. In contrast, there were no significant differences between baseline and 26 weeks in the control group.

Support for the Neuroprotective Effects of Testosterone

Dr. Davison called these results "exciting," and said they provide more evidence that testosterone exerts neuroprotective effects.In men, age-related declines in testosterone increase the risk for Alzheimer's disease, she said. It's been shown that healthy older men and men with mild cognitive impairment and early dementia have demonstrated improvements in cognitive performance, including memory, after testosterone treatment.

"There obviously is some important link between testosterone and cognition that needs to be explored further," Dr. Davison said.

The testosterone spray used in the study is "novel," she noted, "in that it uses a propellant of sunscreen to introduce the testosterone into the skin."

Source:   Medscape Medical News for ENDO 2011: The Endocrine Society 93rd Annual Meeting: Abstract P1-314. Presented June 4, 2011.