Posted by on July 18, 2012 - 4:03pm

We know that many women use contraceptives to prevent unwanted pregnancy often for social, career or economic reasons. In other words, it's not the right time.   There are also health reasons for avoiding or delaying pregnancy.   The Association of Reproductive Health Professional has identified conditions associated with increased risk for adverse health events as a result of pregnancy.  This does NOT mean that all women with these conditions should never get pregnant, but they should have serious discussions with their health providers before they become pregnant, and in some cases, may need to avoid.  Conditions that could lead to a complicated or risky pregnancy, putting the woman at risk include

  • Breast cancer
  • Complicated valvular heart disease
  • diabetes;  insulin dependent with complications
  • Endometrial or ovarian cancer
  • epilepsy
  • Hypertension (high blood pressure)
  • Bariatric Surgery in the past two years
  • HIV/AIDS
  • Ischemic heart disease
  • Malignant liver tumors and certain liver disease
  • Peripartum cardiomyopathy
  • sickle cell disease
  • Solid organ transplant within the past two years
  • stroke
  • systemic lupus
  • platelet mutations
  • tuberculosis

When politicians debate access to contraception and insurance coverage, they need to be aware that there are conditions women may have that put them at high risk for a complicated pregnancy.  Having access to contraceptive methods is critical to planning and/or preventing pregnancy in high risk women.  It's not always about the baby---in these cases,  it is the potential mother!

 

Posted by on July 11, 2012 - 10:31am

In a study recently published by the International Journal of Eating Disorders, women in their early 50’s (midlife) show more symptoms of disordered eating and concerns over their weight and shape than women in their late adulthood (mid 50’s and over).  The concerns are comparable to those expressed only in young women.

Hoping to better understand the weight and shape concerns of women over the age of 50, researchers gathered data from this population through an online survey.  Clinical studies have shown an occurrence of late-onset eating disorders and an increase in inpatient admissions for women over the age 35.  Reports show that there are three ways the disorders appear: a chronic presentation of an earlier-onset eating disorder that the patient never fully recovered from, a relapse of a disorder that the patient has previously experienced, or the late-onset of a disorder without having previously experienced it.

According to separate population-based studies, while the majority of women with eating disorders over 40 did not present with late-onset eating disorders, 69% of the cases studied in women over 50 concluded that the disorder was late-onset.  So at this age, many women are dealing with a new disorder that may negatively impact their lives.

Studies have found that body dissatisfaction remains somewhat stable throughout the lifetime, with surges among younger women and midlife women.  Higher incidence of reported body dissatisfaction occurs among midlife women with a higher BMI.  Physiologically, the BMI of a woman typically
increases during midlife, levels off and then decreases around the age of 60 (among other bodily changes).  Interestingly, areas of dissatisfaction in younger women seem to remain the same into adulthood even with a changing body and changing fat distribution.

The study (published by the International Journal of Eating Disorders) found that 71.2% of women were attempting to lose weight at the time of the survey with 35.6% spending at least half of their time dieting in the last five years.  Overall, 41.2% checked their body size/shape at least daily and 40% weighed themselves at least a couple of times per week.  Vomiting (1.2%), laxatives (2.2%), diuretics (2.5%), diet pills (7.5%) and excessive exercise (6.8%) were the behaviors women reportedly used to control their weight within the last five years.

61.8% said their concerns occasionally or often negatively affected their lives and 79.1% said their weight/shape had either a moderate or even the most important role in how they perceive themselves.  63.9% reported thoughts about their weight daily or more.  Most women had no history of eating disorders (59%); however, 13.3% of those sampled said they currently showed eating disorder symptoms while 27.7% had in the past.

The researchers concluded that younger midlife women showed more disordered eating/weight concerns. A possible explanation in the discrepancy of rates of disorders and concerns among younger midlife women relative to late adulthood is the cohort effect, in which these midlife women may have been exposed to different, and perhaps a greater amount of, socio-cultural pressures than those in later adulthood.  Another explanation may be that body health and function becomes more important than physical appearance in late adulthood.  Also, midlife women may be experiencing symptoms of menopause that prompts an increase in fat and how it is distributed, compounded by a decreased metabolism that may put them at risk for disorders.

Sources:

http://onlinelibrary.wiley.com/doi/10.1002/eat.22030/full

Posted by on July 9, 2012 - 2:39pm

In many women with recurrent breast cancer, the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status of their tumors changes between treatment for the primary tumor and relapse, a large retrospective study has found. The findings, published June 18 in the Journal of Clinical Oncology, support previous studies that have also detected changes in these biomarkers during cancer progression.

These three biomarkers help doctors choose the best treatments for individual women. Therefore, tumors that recur in the breast or appear elsewhere in the body should be biopsied “as a routine procedure” because the results may influence treatment decisions, recommended the authors led by Dr. Linda Lindström of Cancer Center Karolinska in Sweden.

Dr. Lindström and her colleagues used information from pathology reports for 1,010 women treated at three hospitals in Stockholm, all of whom had biopsies taken from their primary and recurrent breast tumors.

Primary and recurrent tumors from 459 women were tested for ER expression. In almost 33 percent of those women, the ER status of the tumor changed (ER expression started or stopped) between treatment and relapse. More than 40 percent of the 430 women whose tumors were tested for PR expression had a change in PR status between treatment and relapse. And almost 15 percent of the 104 women whose primary and recurrent tumors were tested for HER2 expression had a change in HER2 status between treatment and relapse.

In women whose cancers relapsed multiple times, similar proportions of changes to biomarkers were observed.

Prior treatment appeared to influence some biomarker changes. For example, women previously treated with hormone therapy were more likely than women who did not receive hormone therapy to have changes in tumor ER expression. The authors also found that women with ER-positive primary tumors that lost ER expression at relapse had a higher risk of death than women with stable tumor ER expression.

Treatment for metastatic breast cancer is often based on primary tumor characteristics. For some patients, biopsy results will show that the tumor has changed. Therefore, “verifications will be important and may change management options,” concluded the authors.

Posted by on July 7, 2012 - 2:30pm

Despite stable rates of HIV diagnosis in older populations, the rate of HIV diagnoses from 2006 to 2009 increased in teens 15-19 and youth 20-24 years of age, and was highest in the 20-24 year-old age group.  Undiagnosed HIV cases are also thought to be highest among young people. The U.S. Centers for Disease Control and Prevention (CDC) estimates more than half of all undiagnosed HIV infections are youth ages 13 – 24.3.

Of adolescent HIV diagnoses, almost 70 percent are to black teens, even though they constitute a much smaller proportion of the adolescent population in the U.S.    Almost 80 percent of all adolescent infections are to males. Nine out of 10 adolescent male HIV infections result from male-to-male sexual contact. The same proportion of adolescent females is infected from heterosexual contact.

The highest concentrations of HIV diagnoses among adolescents are in the Southeastern United States and, specifically, Florida, South Carolina, and Louisiana.
Although HIV testing is widely available, self-reported rates of HIV testing have remained flat in recent years. Forty-six percent of high school students have had sex at least once, yet only 13 percent report ever having had an HIV test.

Posted by on July 5, 2012 - 2:20pm
  • High humidity. When the humidity is high, sweat won't evaporate as quickly, which keeps your body from releasing heat as fast as it may need to.
  • Personal factors. Age, obesity, fever, dehydration, heart disease, mental illness, poor circulation, sunburn, and prescription drug and alcohol use can play a role in whether a person can cool off enough in very hot weather.
  • People who are at highest risk are the elderly, the very young, and people with mental illness and chronic diseases
  • But even young and healthy people can get sick from the heat if they participate in strenuous physical activities during hot weather.

Air-conditioning is the number one protective factoragainst heat-related illness and death. If a home is not air-conditioned, people can reduce their risk for heat-related illness by spending time in public facilities that are air-conditioned.

Here's what you can do to prevent heat-related illnesses, injuries, and deaths during hot weather:

  • Stay in an air-conditioned indoor location
  • Drink plenty of fluids.
  • Wear loose, lightweight, light-colored clothing and sunscreen.
  • Schedule outdoor activities carefully.
  • Pace yourself.
  • Take cool showers or baths to cool down.
  • Check on a friend or neighbor and have someone do the same for you.
  • Do not leave children in cars.
  • Check the local news for health and safety updates.
Posted by on July 3, 2012 - 12:15pm

 Consuming a low carbohydrate-high protein diet -- like the Atkins diet -- may be associated with a greater risk of cardiovascular disease in women.   Decreases in carbohydrate intake and increases in protein intake  were all associated with significantly greater risks of incident cardiovascular disease events in young Swedish women, according to Pagona Lagiou, MD, PhD, of the University of Athens in Greece, and colleagues.

The findings, which were reported online in BMJ, "do not answer questions concerning possible beneficial short-term effects of low carbohydrate or high protein diets in the control of body weight or insulin resistance," the authors wrote.   "Instead, they draw attention to the potential for considerable adverse effects on cardiovascular health of these diets when they are used on a regular basis," they wrote.

Low carb-high protein diets have become popular because of the short-term effects on weight control, but concerns have been raised about the potential cardiovascular effects over the long term. Studies exploring the issue have given mixed results, with a U.S. study showing no relationship between such a diet and rates of ischemic heart disease.   But three European studies showed a greater risk of cardiovascular mortality with such a diet.

The current analysis included 43,396 women, ages 30 to 49 at baseline, who completed a comprehensive questionnaire on lifestyle and dietary factors, as well as medical history. They were followed for an average of 15.7 years.   During follow-up, there were 1,270 incident cardiovascular events, which included ischemic heart disease, ischemic stroke, hemorrhagic stroke, subarachnoid hemorrhage, and peripheral arterial disease.

After adjustment for energy intake, saturated and unsaturated fat intake, and numerous cardiovascular risk factors, each one-point decrease in carb intake was associated with a relative 4% increase in cardiovascular events (95% CI 0% to 8%). There was a suggestion that the associations were stronger for women whose protein came mostly from animal sources, but the test for interaction did not reach statistical significance for nearly all of the individual outcomes.

"Although these results are based on an observational study, their biological plausibility seems self evident," according to Anna Floegel, MPH, of the German Institute of Human Nutrition Potsdam-Rehbruecke, and Tobias Pischon, MD, MPH, of the Max Delbrück Center for Molecular Medicine Berlin-Buch.

"A low carbohydrate diet implies low consumption of whole-grain foods, fruits, and starchy vegetables and consequently reduced intake of fiber, vitamins, and minerals. A high protein diet may indicate higher intake of red and processed meat and thus higher intake of iron, cholesterol, and saturated fat," they explained in an accompanying editorial.

"These single factors have previously been linked to a higher risk of major chronic diseases, including cardiovascular disease, in observational studies, so it is not surprising that this combination of risk factors is linked to a higher incidence of disease and mortality," they said.

For more informations about preventing heart disease, visit:   2011 Guidelines for CVD Prevention in Women

Primary source: BMJ
Lagiou P, et al "Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study" BMJ 2012; DOI:10.1136/bmj.e4026.

 

Posted by on July 1, 2012 - 11:59am

Chlorine can kill germs in the pool, but it can’t work miracles. At the Centers for Disease Control and Prevention, Michele Hlavsa says the idea that swimming pool disinfectants kill germs instantly is a myth. She says that’s why it’s unhealthy to treat the pool like a toilet, and healthy to shower off any germs before getting in.

Mostly, people just have fun. But Hlavsa notes they can get a variety of diseases.

“They can get gastrointestinal infections, viral meningitis, ear infections – also known as swimmer’s ear – but the most common infection is diarrhea.”

So, she advises, don’t swallow the water, or swim with open sores.

Posted by on June 28, 2012 - 1:28pm

The Supreme Court's decision to uphold the health care law (Affordable Care Act) will keep in place important benefits to women:

  • Women will no longer  be charged more than men for the same health coverage  by insurance companies because women use more health services (preexisting conditions??)
  • Preventive health services like mammograms, birth control, and well women visits will be covered without a co-pay or deductible.
  • Women will no longer be denied health coverage for having survived domestic violence or rape, or having had a Caesarean section.
  • Maternity care will be included in all health care plans.
  • Low income and underserved women will gain financial access to coverage, whether through the Medicaid program or help with insurance premiums.

While the opponents to ACA will turn this into a political battle, the Supreme Court has added credence to the need to create a health care system that benefits all people.  Hopefully, our country's leadership will spend more time on improving this Act rather than spending energy tearing it apart and pandering political rhetoric.

Posted by on June 22, 2012 - 1:48pm

The American Medical Association's House of Delegates has come out in support of routine screening mammography for women starting at age 40.

The new policy is in direct conflict with the controversial 2009 recommendation of the United States Preventive Services Task Force (USPSTF) that routine screening mammography for breast cancer was unnecessary in women younger than 50.

The House of Delegates stopped short of recommending that "every woman should get routine screening mammograms every year starting at age 40". Strongly debated in Tuesday morning's session, that language was rejected by the delegates in favor of a lighter "should be eligible" phrasing.

In a further slap at the federal task force, the House of Delegates voted to adopt a resolution stating that the AMA "expresses concern regarding recent recommendations by the USPSTF on screening mammography and prostate specific antigen (PSA) screening and the effects these recommendations have on limiting access to preventive care for Americans."

The firestorm that followed the USPSTF recommendations attracted congressional attention from legislators and HHS secretary Kathleen Sebelius eventually issued a statement emphasizing that the USPSTF does not set health policy (Editorial comment:  Then why do it?)

A number of medical groups, including the American Cancer Society, the American College of Radiology , and the American Congress of Obstetricians and Gynecologists disagreed with the USPSTF recommendations and said women younger than 50 benefit from having routine mammograms.

The USPSTF again set off a controversy in 2011 when it said that healthy men do not need prostate cancer screening with prostate specific antigen (PSA) because the test does not save lives and often leads to unnecessary testing, interventions, and treatment. The conclusion came after the USPSTF reviewed data from five large randomized clinical trials of PSA testing, which all found found no mortality benefit among men who underwent screening PSA testing and were followed for 10 years.

The PSA recommendation has been controversial in the medical community, especially after a major European trial showed routine testing in healthy men resulted in about a 21% reduction in the rate of prostate cancer deaths after 11 years of follow-up.

In both instances, speciality medical societies were not happy that they weren't involved in drafting the cancer screening guidelines, and on Tuesday, the AMA adopted another policy encouraging the USPSTF to implement procedures that "allow for meaningful input" from specialists.

The USPSTF is an independent panel 16 volunteer members, most of whom are clinicians in primary care or preventive medicine.

Posted by on June 20, 2012 - 12:06pm

Thank you to all who attended TEDxNU: The Complex World of Fertility last night. We had a great time listening to the speakers and even got a chance to see some entertaining and enlightening clips from other TED talks. A special thanks to Sharon Green, the emcee for the evening, and to Dr. Uzzi, Dr. O'Halloran, and Dr. Woodruff, who blew us away with their discussions of collaborative science, reproductive health, and breakthroughs in fertility preservation research.

Are you interested in the mystery of life?  Complexity science?  Infertility? Or the changing process of scientific discovery? Are you a TED or TEDx fan? Check out the webcast videos from this event that will be posted to our website and on this blog in a couple of weeks. To learn more about the topics and speakers, visit www.tedx.northwestern.edu.

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