A new study found that women who were taking hormone replacement therapy (HRT) at least for 6 month after total knee or hip arthroplasty demonstrated a reduced rate of implant failure. The most common reason for implant failure is aseptic loosening of the implant due to osteolysis (degeneration) of the bone surrounding the implant.. HRT is approved to prevent bone loss though many women reject HRT due to other concerns about side effects. To learn more about the benefits and risks of HRT, visit menopauseNU.org