Catherine Woolley, PhD, “Development of an ERβ antibody to study estrogen and depression”

Catherine Woolley, PhD, “Cryo-Immuno electron microscopy to study estrogen-sensitive synaptic vesicles”

• Determined that all commercially available ERβ antibodies are not specific.  Dr. Woolley is using these findings to alert the research community who has routinely used these reagents in publications and grant proposals.  It is necessary to prevent additional investigators from drawing incorrect conclusions from faulty reagents. One manuscript is in preparation describing these findings.
• Discovered a novel new mode of estrogen action in the brain region important in learning and memory, anxiety/depression, and seizure activity in epilepsy. After further experiments are conducted, a manuscript describing the findings and an R21 or R01 will be submitted.