We are very excited to announce the recipients of this year’s Shaw Family Pioneer Awards- Jelena Radulovic, MD, PhD and Aline Martin, PhD.

The Shaw Family Pioneer Awards, provide funding for investigators conducting sex-based and sex-inclusive research. Funding enables early career investigators to conduct pilot studies that may enhance their ability to compete for federal grants. All proposals were evaluated based on the impact, innovation, approach and relevance to sex-based research. 

Dr. Radulovic is a Professor of Psychiatry and Behavioral Sciences, Pharmacology and Physiology at Northwestern University. Dr. Radulovic’s research focuses on the molecular and cellular mechanisms by which memories of stressful events can contribute to anxiety and depression like behaviors. Dr. Radulovic plans to use funds from the Shaw Family Pioneer Award to develop a new method for studying the role of oxytocin receptors in generating patterns of neuronal activity in response to stress in both female and male mice. This project includes some of the latest technology which will allow for visualization of the activity of individual neurons in freely moving mice as they perform behavioral tasks to assess anxiety, memory and social behaviors. The findings will help with constructing new frameworks for sex specific behavioral regulation that can then be translated into human research.

Dr. Martin is an Assistant Professor of Medicine (Nephrology and Hypertension). Dr. Martin plans to focus on chronic kidney disease (CKD) and cardiovascular disease. Cardiovascular disease is the leading cause of death in patients that have CKD. CKD is higher in women but men progress CKD more rapidly. Dr. Martin will investigate the onset of CKD and elevations of fibroblast growth factor 23 (FGF23), which is responsible for regulating phosphorous and vitamin D metabolism, in both male and female mice. This work is relevant to sex-based discoveries because it will focus on cardiovascular disease mortality and the gender-disparities in CKD. This research is innovative in many ways, including that it will be the first study to identify specific gender based molecular mechanisms of cardiac injury. Funding from this award will support Dr. Martin’s goal in producing additional preliminary data that will establish the foundation for an NIH R01 grant application. This grant application will focus on mechanisms of cardiac injury and gender disparities in chronic kidney disease.

Stay tuned for updates in the coming months from the awardees! 

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